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The maximum recommended daily dose of Ranexa is 1000 mg twice daily.

Crushing, dissolving, or chewing the tablet can cause rapid release and absorption of a potentially fatal dose of morphine.

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CHECK WITH YOUR DOCTOR BEFORE EATING GRAPEFRUIT or drinking grapefruit juice while taking this medicine.

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The main therapeutic measure is hyperhydration (by administering intravenous fluids), and if necessary the use of diuretics (to prevent fluid overload).

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Symptoms may include confusion; double vision; fainting; numbness, burning, prickling, or tingling of the skin; severe or persistent dizziness, nausea, or vomiting.

How is angina treated?

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There are no studies of concomitant use of Ranexa with other drugs metabolized by CYP2D6, such as tricyclic antidepressants and antipsychotics, but lower doses of CYP2D6 substrates may be required.

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Angina pain, however, can be just as intense -- and sufferers can be doubled over in agony several times a week.

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This document does not contain all possible drug interactions.

Ok, so I go home and have some chest pains, but not bad, until about 5 months later.

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Nitroglycerin causes the veins (vessels that return blood to the heart) to relax so that the work load of the heart is reduced.

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Ranexa is a prescription medicine used to treat angina that keeps coming back (chronic angina).

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Angina, nausea, and, frightening to others, my face would turn deathly white during the episodes, while my surroundings would appear black or gray, while I fought to stay conscious.

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These included both randomized trials and retrospective cohort studies concerning the use of ranolazine in different clinical settings; prevention of atrial fibrillation in patients with acute coronary syndrome, prevention as well as conversion of postoperative atrial fibrillation after coronary artery bypass grafting, conversion of recent-onset atrial fibrillation, sinus rhythm maintenance in drug-resistant recurrent atrial fibrillation and facilitation of electrical cardioversion in cardioversion-resistant patients.

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Tell your doctor about all the prescription and over-the-counter medications you use.

Nitrates cause dilation of blood vessels, which reduces stress on the heart muscle, thereby reducing the cardiac demand for oxygen.

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Keep Ranexa and all medicines out of the reach of children.

Do not use this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

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Don't forget to include some strength training and stretching in your workouts, too.

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Limit the dose of Ranexa to 500 mg BID when coadministered with diltiazem, verapamil, or other moderate CYP3A inhibitors.

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QT-prolonging drugs, potassium channel variants resulting in a long QT interval, in patients with a family history of (or congenital) long QT syndrome, or in patients with known acquired QT interval prolongation.

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Grapefruit and grapefruit juice may increase the effects of ranolazine by increasing the amount of medicine in the body.

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